The Mayo Clinic Practical Proton Therapy Seminar and Workshop is designed to give radiation oncologists, medical physicists, dosimetrists, therapists, medical residents and physics residents, a focused interactive educational experience in implementing pencil beam scanning therapy. The seminar includes lectures on the basic principles of proton beam therapy, proton beam clinical trials, and practical discussions through case based vignettes with experienced proton beam faculty. The interactive workshop allows for faculty to share how proton beam therapy is implemented in our clinic with hands-on demonstrations of patient immobilization at CT simulation, treatment planning and evaluation, IGRT and beam delivery, including comprehensive QA.