The conference will bring together scientists working to better understand nuclear and genome organisation in various organisms, tissues, and cell states. Conference sessions will cover topics related to: ● Nuclear and subnuclear structure and function ● Hierarchies in nuclear organisation and chromosome topology in the context of gene expression ● Hierarchies in nuclear organisation and chromosome topology in the context of DNA replication and repair ● Crosstalk between transcription and repair ● Technologies for the study of nuclear and genome structure and function ● Nuclear bodies including the nucleolus, PML bodies, heterochromatin, Cajal bodies. ● Biomolecular condensates and phase separation in the nucleus ● Cohesin functions, topologically associated domains and transcription in genome control ● DNA mobility and chromatin dynamics ● Signalling cues, cellular states and genome organisation ● Genome organisation in pluripotency, differentiation, and development ● Nuclear and genome structures in health, cancer, aging, and age-related diseases ● Chromatin loops and non-canonical nucleic acids structures in genome expression and stability ● Spatial genome organisation: from the bench to the bedside Workshops will cover: Technical advances in the study of nuclear and genome organisation; The next frontiers in spatial genome organisation and its connection to health and disease; How to publish in the era of spatial genome organisation?