The purpose of the conference is to provide a forum for the presentation and discussion of the most recent research and industrial developments in the theoretical and practical aspects of safety and security engineering. This field, due to its special nature, is an interdisciplinary area of research and application that brings together, in a systematic way, many disciplines of engineering from the traditional to the most technologically advanced. The conference covers areas such as crisis management, security engineering, natural disasters and emergencies, terrorism, IT security, man-made hazards, pandemics, transportation security, protection and mitigation issues, among others. Authors are encouraged to submit abstracts in all areas of Safety and Security, with particular attention to integrated and interdisciplinary aspects. The conference covers also all aspects of risk management and hazard mitigation, associated with both natural and anthropogenic hazards. Current events help to emphasise the importance of the analysis and management of risk to planners and researchers around the world. Natural hazards such as floods, earthquakes, landslides, fires, epidemics, transportation, climate change, fake news and others have always affected human societies. The more recent emergence of the importance of man-made hazards is a consequence of the rapid technological advances made in the last few centuries. The interaction of natural and anthropogenic risks adds to the complexity of the problems. The meeting aims to attract papers in all related fields, in addition to those listed under the Conference Topics, as well as case studies describing practical experiences. This conference combines the International Conference on Safety and Security Engineering that has been held in Rome (2005), Malta (2007), Rome (2009), Antwerp (2011), Rome (2013), Opatija (2015), Rome (2017), Ancona (2019) and online due to the Covid-19 pandemic in 2021; and the International Conference on Risk Analysis which started in Valencia (1998) and continued in Bologna, (2000); Sintra (2002); Rhodes (2004); Malta (2006); Cephalonia (2008); the Algarve (2010), Brac (2012), the New Forest, home of the Wessex Institute of Technology (2014), Crete (2016), Seville (2018) and online in 2020.